Association between periodontal disease and acute coronary syndrome.

OBJECTIVE To evaluate the relationship between PD and ACS and the association of PD and periodontitis in ACS patients. METHODS Fifty-eight ACS patients and 57 controls with no history of coronary artery disease (CAD) were included in the study. VARIABLES arterial hypertension, diabetes, dyslipidemia, obesity, history of CAD, cigarette smoking, and interleukin-1beta gene polymorphism. RESULTS One hundred and fifteen subjects were enrolled in the study. In the ACS group, 58 patients were evaluated, 32 of whom (55.2%) were male and 26 (44.8%), female. In the control group, 57 subjects were evaluated, 32 (56.1%) of whom were male and 25 (43.9%), female. Periodontal disease was diagnosed in 26 (44.8%) ACS patients and 15 (26.6%) control patients (beta2 = 4.43, p = 0.04). In a logistic regression analysis, the odds ratio for association between PD and ACS was 1.8 (95% CI: 1.0-5.0); p = 0.24. The odds ratio for association of periodontitis with ACS was 4.5 (95% CI: 1.3-15.6); p = 0.019. CONCLUSION No independent association was found between PD and ACS. There was an independent association between periodontitis and ACS.